| Allstate 400 at the Brickyard | Indianapolis Motor Speedway | Sunday, July 25, 2010, TBA |
| Allstate 400 Practice & Qualifying | Indianapolis Motor Speedway | July 23, 2010 - July 24, 2010 |
| AMA Supercross | Lucas Oil Stadium | Saturday, February 20, 2010, 7:00 pm |
| Big Ten Mens Basketball Tournament | Conseco Fieldhouse | March 11, 2010 - March 14, 2010 |
| Harlem Globetrotters | Conseco Fieldhouse | Wednesday, April 14, 2010, 7:00 pm |
| Indiana Ice | Pepsi Coliseum | February 12, 2010 - March 27, 2010 |
| Indiana Pacers | Conseco Fieldhouse | February 9, 2010 - April 12, 2010 |
| Indy 500 | Indianapolis Motor Speedway | Sunday, May 30, 2010, TBA |
| Kroger 200 | O\'Reilly Raceway Park | Saturday, July 24, 2010, TBA |
| Miller Lite Carb Day | Indianapolis Motor Speedway | Friday, May 28, 2010, TBA |
| Monster Jam | Lucas Oil Stadium | Saturday, January 29, 2011, 7:00 pm |
| NCAA Mens Final Four | Lucas Oil Stadium | April 3, 2010 - April 5, 2010 |
| WWE - World Wrestling Entertainment | Conseco Fieldhouse | Monday, February 22, 2010, 8:15 pm |
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| Academy of St Martin | Clowes Memorial Hall | Saturday, April 10, 2010, 8:00 pm |
| Bassnectar | Vogue Theatre - IN | Thursday, April 8, 2010, 9:00 pm |
| Bela Fleck | Clowes Memorial Hall | Friday, February 19, 2010, 8:00 pm |
| Bill Gaither & Homecoming Friends | Conseco Fieldhouse | Friday, May 21, 2010, 7:00 pm |
| Carrie Underwood | Conseco Fieldhouse | Friday, April 9, 2010, 7:30 pm |
| Celtic Woman | Murat Theatre | Saturday, March 27, 2010, 8:00 pm |
| Chevelle | Murat Egyptian Room | Friday, February 19, 2010, 8:00 pm |
| Citizen Cope | Vogue Theatre - IN | Tuesday, March 2, 2010, 8:00 pm |
| Dark Star Orchestra | Murat Egyptian Room | Friday, February 12, 2010, 8:30 pm |
| David Gray | Murat Theatre | Wednesday, March 24, 2010, 7:30 pm |
| Electric Six | Vogue Theatre - IN | Friday, April 2, 2010, 9:00 pm |
| Flogging Molly | Murat Egyptian Room | Monday, March 8, 2010, 7:00 pm |
| Great Big Sea | Vogue Theatre - IN | Thursday, March 18, 2010, 8:00 pm |
| Harry Connick Jr | Murat Theatre | Sunday, February 28, 2010, 7:00 pm |
| Here Come the Mummies | Vogue Theatre - IN | Friday, February 19, 2010, 9:00 pm |
| Jack's Mannequin | Murat Egyptian Room | Wednesday, February 24, 2010, 7:00 pm |
| Jay-Z | Conseco Fieldhouse | Saturday, March 20, 2010, 7:00 pm |
| Keith Emerson | Murat Theatre | Sunday, April 18, 2010, TBA |
| Keith Urban | Indiana State Fairgrounds | Saturday, August 14, 2010, 7:30 pm |
| Killswitch Engage | Murat Egyptian Room | Sunday, February 21, 2010, 7:30 pm |
| Lotus | Vogue Theatre - IN | Thursday, February 18, 2010, 8:00 pm |
| Lucero | Vogue Theatre - IN | Thursday, February 11, 2010, 8:00 pm |
| Martin Sexton | Vogue Theatre - IN | Thursday, April 22, 2010, 8:00 pm |
| Megadeth | Murat Theatre | Thursday, March 11, 2010, 8:00 pm |
| Michael Buble | Conseco Fieldhouse | Tuesday, June 29, 2010, 8:00 pm |
| Needtobreathe | Vogue Theatre - IN | Thursday, March 25, 2010, 8:00 pm |
| Norah Jones | Murat Theatre | Saturday, March 13, 2010, 8:00 pm |
| Randy Travis | Murat Theatre | Sunday, April 11, 2010, 8:00 pm |
| Rascal Flatts | Indiana State Fairgrounds | Saturday, August 7, 2010, 7:30 pm |
| Reverend Horton Heat | Vogue Theatre - IN | Friday, May 14, 2010, 8:00 pm |
| Sevendust | Eight Seconds Saloon | Wednesday, February 24, 2010, 7:00 pm |
| Sugarland | Indiana State Fairgrounds | Friday, August 20, 2010, 7:30 pm |
| The Avett Brothers | Murat Egyptian Room | Sunday, February 28, 2010, 7:30 pm |
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| 101 Dalmatians - The Musical | Clowes Memorial Hall | March 9, 2010 - March 14, 2010 |
| A Chorus Line | Clowes Memorial Hall | April 20, 2010 - April 25, 2010 |
| Cirque du Soleil: Alegria | Conseco Fieldhouse | February 11, 2010 - February 14, 2010 |
| D. L. Hughley | Murat Egyptian Room | Sunday, February 14, 2010, 8:00 pm |
| Gabriel Iglesias | Murat Theatre | Saturday, March 20, 2010, 7:00 pm |
| Jeff Dunham | Indiana State Fairgrounds | Wednesday, August 18, 2010, 8:00 pm |
| Jersey Boys | Murat Theatre | June 9, 2010 - July 3, 2010 |
| John Edward | Indianapolis Marriott Downtown | Wednesday, April 7, 2010, 7:00 pm |
| Ladies Nite Out | Murat Theatre | Saturday, February 13, 2010, 8:00 pm |
| Legally Blonde | Clowes Memorial Hall | May 4, 2010 - May 9, 2010 |
| Ralphie May | Murat Egyptian Room | Friday, March 12, 2010, 8:00 pm |
| Stars on Ice | Conseco Fieldhouse | Wednesday, May 5, 2010, 7:00 pm |
| The Mikado | Clowes Memorial Hall | March 19, 2010 - March 21, 2010 |
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