| Baltimore Orioles | Camden Yards | April 9, 2010 - October 3, 2010 |
| Black Eyed Susan Stakes | Pimlico Race Course | Friday, May 14, 2010, TBA |
| Face Off Classic NCAA Lacrosse | M&T Bank Stadium | Saturday, March 6, 2010, 11:00 am |
| Monster Jam | 1st Mariner Arena | February 26, 2010 - February 28, 2010 |
| Navy Midshipmen Football | M&T Bank Stadium | Saturday, September 4, 2010, TBA |
| NCAA Lacrosse Championships | M&T Bank Stadium | May 29, 2010 - May 31, 2010 |
| Preakness Stakes | Pimlico Race Course | Saturday, May 15, 2010, TBA |
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| Alicia Keys | 1st Mariner Arena | Wednesday, March 24, 2010, 7:30 pm |
| ALO: Animal Liberation Orchestra | The 8x10 | Saturday, May 22, 2010, 8:00 pm |
| Angie Stone | Lyric Opera House | Friday, February 12, 2010, 8:00 pm |
| Beach Boys | Pier Six Concert Pavilion | Saturday, July 24, 2010, 8:00 pm |
| Ben Folds | Rams Head Live | Tuesday, March 23, 2010, 8:00 pm |
| Casting Crowns | 1st Mariner Arena | Thursday, February 18, 2010, 7:00 pm |
| Celtic Woman | Hippodrome Performing Arts Center | Saturday, February 20, 2010, 8:00 pm |
| Daughtry | 1st Mariner Arena | Thursday, March 18, 2010, 7:30 pm |
| David Gray | Lyric Opera House | Wednesday, March 31, 2010, 8:00 pm |
| George Clinton | Rams Head Live | Friday, February 26, 2010, 9:00 pm |
| Harry Connick Jr | Lyric Opera House | Thursday, February 18, 2010, 8:00 pm |
| Hot Tuna | Rams Head Live | Tuesday, July 20, 2010, TBA |
| Kenny Loggins | Pier Six Concert Pavilion | Saturday, May 15, 2010, 8:00 pm |
| Martina McBride | 1st Mariner Arena | Saturday, February 20, 2010, 7:30 pm |
| Megadeth | Rams Head Live | Tuesday, March 16, 2010, 7:00 pm |
| Muse | 1st Mariner Arena | Wednesday, March 3, 2010, 7:00 pm |
| Norah Jones | Lyric Opera House | Tuesday, March 30, 2010, 8:00 pm |
| The xx | Sonar | Friday, April 23, 2010, 9:00 pm |
| tobyMac | 1st Mariner Arena | Friday, March 19, 2010, 7:00 pm |
| Willie Nelson | Pier Six Concert Pavilion | Sunday, July 25, 2010, 7:30 pm |
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| Carmen | Lyric Opera House | Sunday, February 14, 2010, 3:00 pm |
| Carol Burnett | Lyric Opera House | Saturday, April 3, 2010, 7:30 pm |
| David Sedaris | Meyerhoff Symphony Hall | Saturday, April 10, 2010, 8:00 pm |
| In the Heights | Hippodrome Performing Arts Center | February 23, 2010 - March 7, 2010 |
| Jeff Foxworthy | 1st Mariner Arena | Saturday, May 1, 2010, 8:00 pm |
| John Edward | BWI Airport Marriott | Thursday, March 11, 2010, 7:00 pm |
| Lewis Black | Meyerhoff Symphony Hall | Friday, February 19, 2010, 8:00 pm |
| Lisa Lampanelli | Meyerhoff Symphony Hall | Friday, April 16, 2010, 8:00 pm |
| Mike Epps | 1st Mariner Arena | Saturday, March 20, 2010, 8:00 pm |
| Phantom Of The Opera | Hippodrome Performing Arts Center | April 8, 2010 - May 9, 2010 |
| Rigoletto | Hippodrome Performing Arts Center | Thursday, March 11, 2010, 8:00 pm |
| Stomp | Hippodrome Performing Arts Center | March 16, 2010 - March 28, 2010 |
| The 39 Steps | Hippodrome Performing Arts Center | June 1, 2010 - June 13, 2010 |
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