| AMA Supercross | Sam Boyd Stadium | Saturday, May 8, 2010, 7:00 pm |
| Bernard Hopkins | Mandalay Bay Events Center | Saturday, April 3, 2010, 6:00 pm |
| Evander Holyfield | Thomas & Mack Center | Saturday, April 10, 2010, 4:00 pm |
| Las Vegas Area 51s | Cashman Field | April 8, 2010 - August 28, 2010 |
| Los Angeles Dodgers | Cashman Field | Wednesday, March 31, 2010, 7:05 pm |
| Monster Jam | Sam Boyd Stadium | Saturday, March 27, 2010, 7:00 pm |
| National Finals Rodeo | Thomas & Mack Center | December 2, 2010 - December 11, 2010 |
| Professional Bull Riders World Cup | Thomas & Mack Center | April 16, 2010 - April 18, 2010 |
| Professional Bull Riders World Finals | Thomas & Mack Center | October 20, 2010 - October 24, 2010 |
| Shane Mosley | MGM Grand Garden Arena | Saturday, May 1, 2010, 6:00 pm |
| UNLV Rebels Football | Sam Boyd Stadium | Saturday, September 4, 2010, TBA |
| WWE - World Wrestling Entertainment | Thomas & Mack Center | Tuesday, March 30, 2010, 6:45 pm |
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| 30 Seconds To Mars | Pearl Concert Theater at Palms Casino Resort | Friday, April 9, 2010, 9:00 pm |
| AC/DC | MGM Grand Garden Arena | Friday, April 9, 2010, 8:00 pm |
| Academy of Country Music Awards | MGM Grand Garden Arena | Sunday, April 18, 2010, 5:00 pm |
| Al Green | Las Vegas Hilton Theater | August 13, 2010 - August 14, 2010 |
| Alicia Keys | Mandalay Bay Events Center | Friday, April 9, 2010, 8:00 pm |
| Angels and Airwaves | Hard Rock - The Joint | Friday, May 28, 2010, 8:00 pm |
| As I Lay Dying | House of Blues-NV | Saturday, May 22, 2010, 5:00 pm |
| Bad Religion | House of Blues-NV | March 26, 2010 - March 27, 2010 |
| Barry Manilow | Paris Las Vegas | March 21, 2010 - July 18, 2010 |
| Brooks and Dunn | MGM Grand Garden Arena | Monday, April 19, 2010, 7:30 pm |
| Bullet for My Valentine | House of Blues-NV | Wednesday, May 12, 2010, 5:30 pm |
| Carole King | MGM Grand Garden Arena | Saturday, July 17, 2010, 8:00 pm |
| Carrie Underwood | Orleans Arena | Saturday, May 22, 2010, 7:30 pm |
| Celine Dion | Caesars Palace | March 15, 2011 - August 14, 2011 |
| Cher | Caesars Palace | April 10, 2010 - July 4, 2010 |
| Chicago | Las Vegas Hilton Theater | Saturday, April 3, 2010, 8:00 pm |
| Conjunto Primavera Mexican Concert | New York New York Hotel & Casino | Saturday, June 12, 2010, 8:15 pm |
| Crosby Stills and Nash | Hard Rock - The Joint | Friday, June 4, 2010, 8:00 pm |
| Daughtry | Orleans Arena | Thursday, April 29, 2010, 7:30 pm |
| Doobie Brothers | Las Vegas Hilton Theater | September 4, 2010 - September 5, 2010 |
| Earth Wind & Fire | Las Vegas Hilton Theater | April 16, 2010 - April 17, 2010 |
| Frank Marino | Imperial Palace Hotel | Wednesday, March 31, 2010, 10:00 pm |
| Garth Brooks | Encore Theater at Encore Las Vegas | Friday, April 9, 2010, 10:30 pm |
| Gary Allan | Treasure Island - NV | Saturday, November 13, 2010, 8:00 pm |
| HIM | House of Blues-NV | Saturday, April 24, 2010, 6:00 pm |
| Jackson Browne | Hard Rock - The Joint | Tuesday, July 20, 2010, 8:00 pm |
| Jay-Z | Pearl Concert Theater at Palms Casino Resort | Saturday, March 27, 2010, 8:00 pm |
| John Mayer | Mandalay Bay Events Center | Saturday, March 27, 2010, 8:00 pm |
| Justin Bieber | Planet Hollywood - Theatre | Saturday, July 24, 2010, 7:00 pm |
| Keith Emerson | Las Vegas Hilton Theater | Saturday, April 24, 2010, 8:00 pm |
| Keith Urban | Hard Rock - The Joint | Friday, April 23, 2010, 8:00 pm |
| Kenny Chesney | Hard Rock - The Joint | May 14, 2010 - July 3, 2010 |
| Legends in Concert | Harrah\'s Las Vegas Casino | Monday, May 31, 2010, 7:30 pm |
| Lionel Richie | Caesars Palace | March 26, 2010 - March 27, 2010 |
| Matt Goss | Caesars Palace | March 26, 2010 - May 28, 2010 |
| Muse | Mandalay Bay Events Center | Saturday, April 10, 2010, 8:00 pm |
| New Kids on the Block | Pearl Concert Theater at Palms Casino Resort | May 7, 2010 - May 8, 2010 |
| Overkill | House of Blues-NV | Monday, April 19, 2010, 5:00 pm |
| Paramore | Hard Rock - The Joint | Sunday, May 16, 2010, 7:00 pm |
| Perry Danos | The Orleans Showroom | April 23, 2010 - April 25, 2010 |
| REO Speedwagon | Thomas & Mack Center | Friday, July 23, 2010, TBA |
| Santana | Hard Rock - The Joint | April 21, 2010 - May 2, 2010 |
| Star Wars In Concert | Orleans Arena | May 29, 2010 - May 29, 2010 |
| Sting | MGM Grand Garden Arena | Friday, June 18, 2010, 8:00 pm |
| The Dead Weather | Pearl Concert Theater at Palms Casino Resort | Sunday, April 18, 2010, 8:00 pm |
| The Eagles | MGM Grand Garden Arena | Saturday, April 24, 2010, 8:00 pm |
| Them Crooked Vultures | Hard Rock - The Joint | Saturday, April 17, 2010, 8:00 pm |
| Thrice | House of Blues-NV | Friday, May 7, 2010, 5:30 pm |
| Vince Gill | Las Vegas Hilton Theater | Saturday, October 23, 2010, 8:00 pm |
| ZZ Top | Las Vegas Hilton Theater | August 20, 2010 - August 21, 2010 |
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| American Storm | V theater at Planet Hollywood Las Vegas | March 26, 2010 - December 10, 2010 |
| Bill Cosby | Treasure Island - NV | July 2, 2010 - July 2, 2010 |
| Blue Man Group | Venetian - Blue Man Theatre | March 21, 2010 - December 31, 2010 |
| Brad Garrett | Mirage Hotel and Casino | June 25, 2010 - June 26, 2010 |
| Cedric the Entertainer | Planet Hollywood - Theatre | Friday, April 30, 2010, 9:00 pm |
| Cheech & Chong | Mirage Hotel and Casino | May 21, 2010 - May 22, 2010 |
| Chelsea Handler | Caesars Palace | Saturday, May 29, 2010, 10:30 pm |
| Cirque du Soleil: KA | MGM Grand KA | March 23, 2010 - April 30, 2010 |
| Cirque du Soleil: Love | Mirage - LOVE Theatre | March 21, 2010 - May 9, 2010 |
| Cirque du Soleil: Mystere | Treasure Island - NV | March 21, 2010 - March 31, 2010 |
| Cirque du Soleil: O | Bellagio | March 21, 2010 - August 26, 2010 |
| Cirque du Soleil: Viva ELVIS | Aria Resort & Casino | Tuesday, April 6, 2010, 9:30 pm |
| Cirque du Soleil: Zumanity | New York New York Hotel & Casino | March 21, 2010 - May 9, 2010 |
| Conan O'Brien | Pearl Concert Theater at Palms Casino Resort | May 1, 2010 - May 2, 2010 |
| David Copperfield | MGM Grand Hollywood Theatre | March 25, 2010 - March 31, 2010 |
| Dennis Miller | The Orleans Showroom | April 16, 2010 - April 18, 2010 |
| Fab Four Live | V theater at Planet Hollywood Las Vegas | March 22, 2010 - December 28, 2010 |
| Frank Caliendo | Lance Burton Theatre | April 8, 2010 - May 31, 2010 |
| Jay Leno | Mirage Hotel and Casino | April 2, 2010 - November 27, 2010 |
| Jerry Seinfeld | Caesars Palace | April 30, 2010 - May 1, 2010 |
| Jersey Boys | Palazzo Resort Hotel Casino | March 21, 2010 - April 15, 2010 |
| John Edward | Flamingo Las Vegas | Saturday, May 8, 2010, 11:00 am |
| Le Reve | Wynn Las Vegas | March 26, 2010 - March 29, 2010 |
| Lewis Black | Mirage Hotel and Casino | May 29, 2010 - November 13, 2010 |
| Louie Anderson | Excalibur Hotel and Casino | March 21, 2010 - March 30, 2010 |
| Peepshow | Planet Hollywood - Showroom | March 21, 2010 - March 30, 2010 |
| Ray Romano | Mirage Hotel and Casino | April 16, 2010 - November 20, 2010 |
| Ron White | Mirage Hotel and Casino | April 9, 2010 - December 11, 2010 |
| Russell Peters | Hard Rock - The Joint | Sunday, May 30, 2010, 9:00 pm |
| Terry Fator | Mirage Hotel and Casino | March 23, 2010 - April 30, 2010 |
| The Phantom | Venetian Hotel & Casino | March 22, 2010 - January 8, 2011 |
| Tim Conway | Las Vegas Hilton Theater | May 14, 2010 - May 15, 2010 |
| Tracy Morgan | Hard Rock - The Joint | Saturday, June 5, 2010, 9:00 pm |
| V-The Ultimate Variety Show | V theater at Planet Hollywood Las Vegas | March 22, 2010 - December 31, 2010 |
| Walking with Dinosaurs | Thomas & Mack Center | Saturday, March 27, 2010, 7:00 pm |
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