| As I Lay Dying | Mr Smalls Theater | May 8, 2010 - May 9, 2010 |
| B.E. Taylor | Heinz Hall | June 17, 2010 - June 20, 2010 |
| Bill Gaither & Homecoming Friends | Mellon Arena | Friday, March 26, 2010, 7:00 pm |
| Brad Paisley | First Niagara Pavilion | Saturday, June 12, 2010, TBA |
| Brooks and Dunn | First Niagara Pavilion | Friday, July 30, 2010, TBA |
| Carole King | Mellon Arena | Saturday, June 26, 2010, TBA |
| Carrie Underwood | Petersen Events Center | Thursday, April 1, 2010, 7:30 pm |
| Celtic Woman | Mellon Arena | Friday, March 19, 2010, 8:00 pm |
| Country Throwdown | First Niagara Pavilion | Saturday, May 29, 2010, TBA |
| Daughtry | Petersen Events Center | Wednesday, June 2, 2010, 7:30 pm |
| Dave Matthews Band | PNC Park | Saturday, July 10, 2010, 7:00 pm |
| David Gray | Benedum Center | Tuesday, March 30, 2010, 6:30 pm |
| Iron Maiden | First Niagara Pavilion | Wednesday, July 14, 2010, TBA |
| Jay-Z | Mellon Arena | Tuesday, March 16, 2010, 7:30 pm |
| Jimmy Buffett | First Niagara Pavilion | Thursday, August 12, 2010, 8:00 pm |
| Johnny Mathis | Heinz Hall | July 9, 2010 - July 10, 2010 |
| Michael Buble | Petersen Events Center | Wednesday, March 17, 2010, 8:00 pm |
| Rascal Flatts | First Niagara Pavilion | Friday, September 17, 2010, TBA |
| Rockstar Energy Mayhem Festival | First Niagara Pavilion | Saturday, August 7, 2010, TBA |
| Straight No Chaser | Byham Theater | Wednesday, April 21, 2010, 7:30 pm |
| Sugarland | First Niagara Pavilion | Friday, May 14, 2010, 7:30 pm |
| The Juliana Theory | Mr Smalls Theater | Saturday, August 21, 2010, 9:00 pm |
| Tim McGraw | First Niagara Pavilion | Thursday, July 8, 2010, TBA |
| Toby Keith | First Niagara Pavilion | Sunday, August 22, 2010, TBA |
| Tom Petty | First Niagara Pavilion | Saturday, July 24, 2010, 7:30 pm |
| Train | Carnegie Music Hall | Thursday, March 25, 2010, 8:00 pm |
| Trans-Siberian Orchestra | Benedum Center | Sunday, April 4, 2010, 7:30 pm |
| Vans Warped Tour | First Niagara Pavilion | Wednesday, July 7, 2010, TBA |
| Wilco | Carnegie Music Hall | Sunday, April 11, 2010, 8:00 pm |
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| Anthony Bourdain | Heinz Hall | Monday, June 14, 2010, 7:30 pm |
| August: Osage County | Benedum Center | April 9, 2010 - April 11, 2010 |
| Cirque de la Symphonie | Heinz Hall | Saturday, April 24, 2010, 8:00 pm |
| David Sedaris | Heinz Hall | Monday, October 11, 2010, 8:00 pm |
| Grease | Benedum Center | Sunday, March 14, 2010, 6:30 pm |
| Hair | Heinz Hall | Saturday, February 19, 2011, 8:00 pm |
| John Edward | Sheraton Station Square | Friday, June 25, 2010, 7:30 pm |
| Mary Poppins | Benedum Center | Saturday, January 15, 2011, 8:00 pm |
| Next to Normal | Benedum Center | Saturday, April 9, 2011, 8:00 pm |
| Rock of Ages | Benedum Center | Saturday, November 27, 2010, 8:00 pm |
| Shrek - The Musical | Benedum Center | Saturday, March 19, 2011, 8:00 pm |
| South Pacific | Benedum Center | Saturday, November 6, 2010, 8:00 pm |
| Stars on Ice | Mellon Arena | Thursday, April 29, 2010, 7:00 pm |
| Swan Lake | Benedum Center | Saturday, April 17, 2010, 8:00 pm |
| West Side Story | Benedum Center | Saturday, May 21, 2011, 8:00 pm |
| Wizard Of Oz | Heinz Hall | April 3, 2010 - April 4, 2010 |
| Young Frankenstein | Benedum Center | May 7, 2010 - May 9, 2010 |
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